MD&M West 2011 Presentation: Anti–Microbial PEEK Solutions

    • Reference:
    • Jaekel, D. Anti–Microbial PEEK Solutions. Presented at the MD&M 2011 conference in Anaheim, CA, February 9, 2011.
    • Keywords:
    • PEEK, bacteria, adhesion, nanosilver, anti-microbial, antibiotic tethering
    • Permissions:
    • The slide show of this presentation is made available on with the permission of the author.

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Polyaryletheretherketone (PEEK) has emerged as the material of choice for spinal fusion instrumentation due to its high strength, biocompatibility, and radiolocuency. However, up to 6.7% of all instrumented fusion surgeries result in infection. These spinal infections have greater morbidity and greater economic burden than its uninfected counterparts. Coupled with PEEK gradually being incorporated into orthopaedic and trauma devices with similar infection profiles, there is a growing interest in the risk of infection on PEEK biomaterials. Recently, studies have emerged focusing on the examination of bacterial adhesion and proliferation on PEEK and methods of biofilm prevention. Research has been conducted into bacterial adhesion profiles on surface topography, and also the influences of oxygen plasma treatment on surface adherence. In addition, within the literature, various coating technologies attempt to put bone attachment at a competitive advantage to bacterial adhesion and promote antibiofouling behavior. Finally, studies are being performed to evaluate active responses to microbial intrusion with both antibacterial silver-PEEK composites and possible antibiotic tethering to PEEK surfaces.