Wear tests were performed at Durham University on PEEK-OPTIMA and carbon fibre reinforced PEEK-OPTIMA (CFR-PEEK) against cobalt chrome molybdenum (CoCrMo) to assess the potential of this material combination for use in orthopaedic implants. Four station pin-on-plate wear machines were used. Multi-directional motion included reciprocation and rotation (1 Hz). 40 N load was applied in 25% bovine serum (protein content 15 gl-1) at 37°C. Specimens were tested to 2 million cycles. CFR-PEEK against CoCrMo (HC or LC) provided low wear rates. This study gives confidence in the likelihood of this material combination performing well in orthopaedic applications.