Few details have been reported on the mechanical properties of Ti- and Hydroxyapatite-coated medical grade PEEK. In this study from the University of Trento, researchers investigated the influence of plasma spraying on the tensile and flexural properties of PEEK and CFR-PEEK. In order to distinguish the effects induced by sandblasting, representing the first step of plasma spray coating process, mechanical characterization has been carried out also on a set of sandblasted PEEK and CFR-PEEK specimens. Scanning electron microscope (SEM) analysis and adhesion measurements of the coatings were carried out in order to characterize the coatings. A properly designed and applied plasma spray process was found to improve the osseoconductivity of PEEK or CFR-PEEK components while modestly varying the tensile and flexural properties.