Efficient detection of eukaryotic calcium-sensing receptor

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In direction of middle-up evaluation of polyclonal antibodies: subclass-specific N-glycosylation profiling of murine immunoglobulin G (IgG) by the use of HPLC-MS

 

  • Lately, superior HPLC-MS methods based mostly on intact protein (“top-down”) or protein subunit (“middle-up/middle-down”) evaluation have been applied for the characterization of therapeutic monoclonal antibodies. Right here, we assess feasibility of middle-up/middle-down evaluation for polyclonal IgGs exhibiting in depth sequence variability. Particularly, we addressed IgGs from mouse, representing an essential mannequin system in immunological investigations.
  • To acquire Fc/2 parts as conserved subunits of IgGs, we made use of the bacterial protease SpeB. For this function, we initially decided SpeB cleavage websites in murine IgGs. The ensuing Fc/2 parts attribute of various subclasses had been subsequently analysed by ion-pair reversed-phase HPLC hyphenated to high-resolution mass spectrometry. This enabled simultaneous relative quantification of IgG subclasses and their N-glycosylation variants, each of which affect IgG effector features.
  • To evaluate methodology capabilities in an immunological context, we utilized the analytical workflow to polyclonal antibodies obtained from BALB/c mice immunized with the grass pollen allergen Phl p 6. The research revealed a shift in IgG subclasses and Fc-glycosylation patterns in whole and antigen-specific IgGs from totally different mouse cohorts, respectively. Finally, Fc/2 characterization might reveal different protein modifications together with oxidation, amino acid exchanges, and C-terminal lysine, and will thus be applied for high quality management of practical antibodies.

Environment friendly detection of eukaryotic calcium-sensing receptor (CaSR) by polyclonal antibody towards prokaryotic expressed truncated CaSR

 

Calcium-sensing receptor (CaSR), which is best identified for its motion as regulating calcium homeostasis, can bind varied ligands. To facilitate analysis on CaSR and perceive the receptor’s operate additional, an in silico designed truncated protein was developed. The ensuing protein folding indicated that 99% of predicted three dimensional (3D) construction residues are positioned in favored and allowed Ramachandran plots. Nonetheless, it was discovered that such protein doesn’t fold correctly when expressed in prokaryotic host cells.

Thioredoxin (Trx) tag was conjugated to extend the ultimate protein’s solubility, which may assist acquire the soluble antigen with higher immunogenic properties. The truncated recombinant proteins had been expressed and purified in two kinds (Trx-CaSR: RR19 and CaSR: RRJ19). The polyclonal antibody was induced by the rabbit immunization with the type of RR19. Western blot on mouse kidney lysates evidenced the correct immune recognition of the receptor by the produced antibody.

The specificity and sensitivity of antibodies had been additionally assayed by immunohistofluorescence. These experiments affirmed antibody’s means to point the receptor on the cell floor in native type and the potential for making use of such antibodies in additional mobile and tissue assays.

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Doxorubicin Hydrochloride (Autophagy inducer)

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Description: Doxorubicin is a semi-synthesized anticancer agent derived from bacterial culture. [1] It is an anthracycline antibiotic. It is been widely used in blood cancers, solid tumors and sarcomas.

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Description: Doxorubicin is a semi-synthesized anticancer agent derived from bacterial culture. [1] It is an anthracycline antibiotic. It is been widely used in blood cancers, solid tumors and sarcomas.

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Description: Doxorubicin is a semi-synthesized anticancer agent derived from bacterial culture. [1] It is an anthracycline antibiotic. It is been widely used in blood cancers, solid tumors and sarcomas.

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Description: Pazopanib HCl is a receptor tyrosine kinase inhibitor that targets multiple kinases, including VEGFR1, VEGFR2, VEGFR3, PDGFR, FGFR, c-Kit, and c-Fms, with IC50s 10nM, 30nM, 47nM, 84nM, 74nM, 140nM, and 146nM respectively [1-3].

Pazopanib Hydrochloride

A8347-5.1 10 mM (in 1mL DMSO)
EUR 135.6
Description: Pazopanib HCl is a receptor tyrosine kinase inhibitor that targets multiple kinases, including VEGFR1, VEGFR2, VEGFR3, PDGFR, FGFR, c-Kit, and c-Fms, with IC50s 10nM, 30nM, 47nM, 84nM, 74nM, 140nM, and 146nM respectively [1-3].

Pazopanib Hydrochloride

A8347-500 500 mg
EUR 727.2
Description: Pazopanib HCl is a receptor tyrosine kinase inhibitor that targets multiple kinases, including VEGFR1, VEGFR2, VEGFR3, PDGFR, FGFR, c-Kit, and c-Fms, with IC50s 10nM, 30nM, 47nM, 84nM, 74nM, 140nM, and 146nM respectively [1-3].

Pazopanib Hydrochloride

A8347-S Evaluation Sample
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Description: Pazopanib HCl is a receptor tyrosine kinase inhibitor that targets multiple kinases, including VEGFR1, VEGFR2, VEGFR3, PDGFR, FGFR, c-Kit, and c-Fms, with IC50s 10nM, 30nM, 47nM, 84nM, 74nM, 140nM, and 146nM respectively [1-3].

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A8621-100 100 mg
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Description: Bestatin hydrochloride, also known as Ubenimex, is an inhibitor of aminopeptidase B and N (APN)/CD13 [1].Bestatin, an antibiotic of microbial origin, is a potent inhibitor of some aminopeptidases which can be administered to cultured cells, intact animals and humans with low toxicity.

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Description: Bestatin hydrochloride, also known as Ubenimex, is an inhibitor of aminopeptidase B and N (APN)/CD13 [1].Bestatin, an antibiotic of microbial origin, is a potent inhibitor of some aminopeptidases which can be administered to cultured cells, intact animals and humans with low toxicity.

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EUR 129.6
Description: Bestatin hydrochloride, also known as Ubenimex, is an inhibitor of aminopeptidase B and N (APN)/CD13 [1].Bestatin, an antibiotic of microbial origin, is a potent inhibitor of some aminopeptidases which can be administered to cultured cells, intact animals and humans with low toxicity.

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A8640-10 10 mg
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Flavopiridol hydrochloride

A8640-100 100 mg
EUR 528
Description: Flavopiridol hydrochloride is a selective inhibitor of CDK1, CDK2, CDK4 and CDK6 with IC50 value all ~41 nM as well as CDK7 with 300nM [1] [2] [3].CDKs are protein kinase families which involve in the process of regulating transcription, mRNA processing, cell differentiation and cell cycle.

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A8640-1000 1 g
EUR 3259.2
Description: Flavopiridol hydrochloride is a selective inhibitor of CDK1, CDK2, CDK4 and CDK6 with IC50 value all ~41 nM as well as CDK7 with 300nM [1] [2] [3].CDKs are protein kinase families which involve in the process of regulating transcription, mRNA processing, cell differentiation and cell cycle.

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A8640-25 25 mg
EUR 199.2
Description: Flavopiridol hydrochloride is a selective inhibitor of CDK1, CDK2, CDK4 and CDK6 with IC50 value all ~41 nM as well as CDK7 with 300nM [1] [2] [3].CDKs are protein kinase families which involve in the process of regulating transcription, mRNA processing, cell differentiation and cell cycle.

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EUR 129.6
Description: Flavopiridol hydrochloride is a selective inhibitor of CDK1, CDK2, CDK4 and CDK6 with IC50 value all ~41 nM as well as CDK7 with 300nM [1] [2] [3].CDKs are protein kinase families which involve in the process of regulating transcription, mRNA processing, cell differentiation and cell cycle.

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A3750-10 10 mg
EUR 150
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A3750-100 100 mg
EUR 282
Description: Regorafenib (BAY 73-4506) is a multikinase inhibitor with IC50 of 17, 40 and 69 nM c-KIT, VEGFR2, B-Raf.

Regorafenib hydrochloride

A3750-200 200 mg
EUR 582
Description: Regorafenib (BAY 73-4506) is a multikinase inhibitor with IC50 of 17, 40 and 69 nM c-KIT, VEGFR2, B-Raf.

Regorafenib hydrochloride

A3750-5.1 10 mM (in 1mL DMSO)
EUR 199.2
Description: Regorafenib (BAY 73-4506) is a multikinase inhibitor with IC50 of 17, 40 and 69 nM c-KIT, VEGFR2, B-Raf.

Regorafenib hydrochloride

A3750-50 50 mg
EUR 199.2
Description: Regorafenib (BAY 73-4506) is a multikinase inhibitor with IC50 of 17, 40 and 69 nM c-KIT, VEGFR2, B-Raf.

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A3755-10 10 mg
EUR 428.4
Description: Resminostat is an inhibitor of histone deacetylase (HDAC) with IC50 values of 42.5nM, 50.1nM and 71.8nM, respectively against HDAC1, 3 and 6 [1].

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A3755-100 100 mg
EUR 1905.6
Description: Resminostat is an inhibitor of histone deacetylase (HDAC) with IC50 values of 42.5nM, 50.1nM and 71.8nM, respectively against HDAC1, 3 and 6 [1].

Resminostat hydrochloride

A3755-5.1 10 mM (in 1mL DMSO)
EUR 464.4
Description: Resminostat is an inhibitor of histone deacetylase (HDAC) with IC50 values of 42.5nM, 50.1nM and 71.8nM, respectively against HDAC1, 3 and 6 [1].

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A3755-50 50 mg
EUR 1209.6
Description: Resminostat is an inhibitor of histone deacetylase (HDAC) with IC50 values of 42.5nM, 50.1nM and 71.8nM, respectively against HDAC1, 3 and 6 [1].

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A3766-10 10 mg
EUR 186
Description: Rimonabant, also known as SR141716, was the first selective central cannabinoid (CB1) receptor inverse agonist (Ki = 1.8 nM) to be developed as an appetite suppressant, anti-obesity drug.

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A3766-100 100 mg
EUR 710.4
Description: Rimonabant, also known as SR141716, was the first selective central cannabinoid (CB1) receptor inverse agonist (Ki = 1.8 nM) to be developed as an appetite suppressant, anti-obesity drug.

Rimonabant hydrochloride

A3766-5.1 10 mM (in 1mL DMSO)
EUR 199.2
Description: Rimonabant, also known as SR141716, was the first selective central cannabinoid (CB1) receptor inverse agonist (Ki = 1.8 nM) to be developed as an appetite suppressant, anti-obesity drug.

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EUR 494.4
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A3777-100 100 mg
EUR 480
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A3777-200 200 mg
EUR 812.4
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Rotigotine hydrochloride

A3777-5.1 10 mM (in 1mL DMSO)
EUR 417.6
Description: Rotigotine is dopamine D2 and D3 receptor agonist. Ki values are 13 and 0.71 nM for D2 and D3 respectively. Rotigotine also has significant affinity for 5-HT1A and adrenergic ?2B receptors. Rotigotine exhibits antiparkinsonian acitivity.

Rotigotine hydrochloride

A3777-50 50 mg
EUR 360
Description: Rotigotine is dopamine D2 and D3 receptor agonist. Ki values are 13 and 0.71 nM for D2 and D3 respectively. Rotigotine also has significant affinity for 5-HT1A and adrenergic ?2B receptors. Rotigotine exhibits antiparkinsonian acitivity.

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A3777-500 500 mg
EUR 1663.2
Description: Rotigotine is dopamine D2 and D3 receptor agonist. Ki values are 13 and 0.71 nM for D2 and D3 respectively. Rotigotine also has significant affinity for 5-HT1A and adrenergic ?2B receptors. Rotigotine exhibits antiparkinsonian acitivity.

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A3875-10 10 mg
EUR 553.2
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Tipiracil hydrochloride

A3875-25 25 mg
EUR 774
Description: Tipiracil is an inhibitor of Thymidine phosphorylase (TP). Thymidine phosphorylase (TP)is a key enzyme in the pyrimidine nucleoside salvage pathway.

Tipiracil hydrochloride

A3875-5 5 mg
EUR 382.8
Description: Tipiracil is an inhibitor of Thymidine phosphorylase (TP). Thymidine phosphorylase (TP)is a key enzyme in the pyrimidine nucleoside salvage pathway.

Tipiracil hydrochloride

A3875-5.1 10 mM (in 1mL DMSO)
EUR 351.6
Description: Tipiracil is an inhibitor of Thymidine phosphorylase (TP). Thymidine phosphorylase (TP)is a key enzyme in the pyrimidine nucleoside salvage pathway.

Tipiracil hydrochloride

A3875-50 50 mg
EUR 1230
Description: Tipiracil is an inhibitor of Thymidine phosphorylase (TP). Thymidine phosphorylase (TP)is a key enzyme in the pyrimidine nucleoside salvage pathway.

Vandetanib hydrochloride

A3906-100 100 mg
EUR 517.2
Description: Description: IC50 Value: 40 nM (VEGFR2) [1]; 500 nM (EGFR) [2] Vandetanib is an anti-cancer drug that is used for the treatment of certain tumours of thethyroid gland.

Vandetanib hydrochloride

A3906-25 25 mg
EUR 201.6
Description: Description: IC50 Value: 40 nM (VEGFR2) [1]; 500 nM (EGFR) [2] Vandetanib is an anti-cancer drug that is used for the treatment of certain tumours of thethyroid gland.

Vernakalant Hydrochloride

A3915-10 10 mg
EUR 847.2
Description: IC50: Vernakalant inhibits two specific potassium currents, IKur (IC50 = 9 ??) and IKACh (IC50=10 ?M) which are only present in atrial myocardium [1].Vernakalant blocks atrial potassium channels, thereby prolonging repolarization.

Vernakalant Hydrochloride

A3915-100 100 mg
EUR 3316.8
Description: IC50: Vernakalant inhibits two specific potassium currents, IKur (IC50 = 9 ??) and IKACh (IC50=10 ?M) which are only present in atrial myocardium [1].Vernakalant blocks atrial potassium channels, thereby prolonging repolarization.

Vernakalant Hydrochloride

A3915-50 50 mg
EUR 2090.4
Description: IC50: Vernakalant inhibits two specific potassium currents, IKur (IC50 = 9 ??) and IKACh (IC50=10 ?M) which are only present in atrial myocardium [1].Vernakalant blocks atrial potassium channels, thereby prolonging repolarization.

Vilazodone Hydrochloride

A3919-10 10 mg
EUR 129.6
Description: Vilazodone (EMD 68843; SB 659746A; 5-{4-[4-(5-cyano-3-indolyl)-butyl]-1-piperazinyl}-benzofuran-2-carboxamide hydrochloride) is a combined serotonin specific reuptake inhibitor (SSRI) and 5-HT1A receptor partial agonist currently under clinical evaluation for the treatment of major depression.

Vilazodone Hydrochloride

A3919-5.1 10 mM (in 1mL DMSO)
EUR 129.6
Description: Vilazodone (EMD 68843; SB 659746A; 5-{4-[4-(5-cyano-3-indolyl)-butyl]-1-piperazinyl}-benzofuran-2-carboxamide hydrochloride) is a combined serotonin specific reuptake inhibitor (SSRI) and 5-HT1A receptor partial agonist currently under clinical evaluation for the treatment of major depression.

Vilazodone Hydrochloride

A3919-50 50 mg
EUR 157.2
Description: Vilazodone (EMD 68843; SB 659746A; 5-{4-[4-(5-cyano-3-indolyl)-butyl]-1-piperazinyl}-benzofuran-2-carboxamide hydrochloride) is a combined serotonin specific reuptake inhibitor (SSRI) and 5-HT1A receptor partial agonist currently under clinical evaluation for the treatment of major depression.

Voreloxin Hydrochloride

A3925-10 10 mg
EUR 895.2
Description: Voreloxin is a small molecule and a naphthyridine analogue with antineoplastic activity. Vosaroxin intercalates into DNA in a site-specific manner and blocks the re-ligation process carried out by topoisomerase II during DNA replication.

Voreloxin Hydrochloride

A3925-5 5 mg
EUR 656.4
Description: Voreloxin is a small molecule and a naphthyridine analogue with antineoplastic activity. Vosaroxin intercalates into DNA in a site-specific manner and blocks the re-ligation process carried out by topoisomerase II during DNA replication.

Voreloxin Hydrochloride

A3925-5.1 10 mM (in 1mL DMSO)
EUR 717.6
Description: Voreloxin is a small molecule and a naphthyridine analogue with antineoplastic activity. Vosaroxin intercalates into DNA in a site-specific manner and blocks the re-ligation process carried out by topoisomerase II during DNA replication.

PJ34 hydrochloride

A4159-10 10 mg
EUR 142.8
Description: PJ34 is a novel and potent inhibitor of poly(ADP-ribose) polymerase (PARP), an enzyme involved in DNA repair and cell proliferation, that dose-dependently inhibits purified PARP enzyme in a cell-free assay with half maximal effective concentration EC50 value of 20 nM.

PJ34 hydrochloride

A4159-5 5 mg
EUR 129.6
Description: PJ34 is a novel and potent inhibitor of poly(ADP-ribose) polymerase (PARP), an enzyme involved in DNA repair and cell proliferation, that dose-dependently inhibits purified PARP enzyme in a cell-free assay with half maximal effective concentration EC50 value of 20 nM.

PJ34 hydrochloride

A4159-5.1 10 mM (in 1mL DMSO)
EUR 150
Description: PJ34 is a novel and potent inhibitor of poly(ADP-ribose) polymerase (PARP), an enzyme involved in DNA repair and cell proliferation, that dose-dependently inhibits purified PARP enzyme in a cell-free assay with half maximal effective concentration EC50 value of 20 nM.

PJ34 hydrochloride

A4159-50 50 mg
EUR 296.4
Description: PJ34 is a novel and potent inhibitor of poly(ADP-ribose) polymerase (PARP), an enzyme involved in DNA repair and cell proliferation, that dose-dependently inhibits purified PARP enzyme in a cell-free assay with half maximal effective concentration EC50 value of 20 nM.

PJ34 hydrochloride

A4159-S Evaluation Sample
EUR 97.2
Description: PJ34 is a novel and potent inhibitor of poly(ADP-ribose) polymerase (PARP), an enzyme involved in DNA repair and cell proliferation, that dose-dependently inhibits purified PARP enzyme in a cell-free assay with half maximal effective concentration EC50 value of 20 nM.

Dimethylamine hydrochloride

DB0410 500g
EUR 116.38

Daunorubicin hydrochloride

D001-10MG 10 mg
EUR 142.8

Daunorubicin hydrochloride

D001-50MG 50 mg
EUR 480

Difloxacin hydrochloride

D021-1G 1 g
EUR 133.2

Difloxacin hydrochloride

D021-5G 5 g
EUR 438

Demeclocycline hydrochloride

D032-1G 1 g
EUR 208.8

Demeclocycline hydrochloride

D032-250MG 250 mg
EUR 105.6

Demeclocycline hydrochloride

D032-5G 5 g
EUR 646.8

Doxycycline Hydrochloride

D065-25MG 25mg
EUR 410.4

Doxycycline Hydrochloride

D065-5MG 5mg
EUR 142.8

Dalbavancin Hydrochloride

D092-10MG 10mg
EUR 152.4

Dalbavancin Hydrochloride

D092-50MG 50mg
EUR 456

Cefepime Hydrochloride

C009-100MG 100 mg
EUR 320.4

Ceftazidime Hydrochloride

C020-1G 1 g
EUR 746.4

Niguldipine (hydrochloride)

C3067-10 10 mg
EUR 164.4
Description: Ki = 0.16 nM: ?1A-adrenoceptor antagonistIC50s = 0.4 ?M: inhibits L-type Ca2+ channelsIC50s = 0.9 ?M: suppresses T-type Ca2+ channelsNiguldipine is a less potent Ca2+ channel blocker and potent, selective ?1A-adrenoceptor receptor antagonist.

Niguldipine (hydrochloride)

C3067-25 25 mg
EUR 308.4
Description: Ki = 0.16 nM: ?1A-adrenoceptor antagonistIC50s = 0.4 ?M: inhibits L-type Ca2+ channelsIC50s = 0.9 ?M: suppresses T-type Ca2+ channelsNiguldipine is a less potent Ca2+ channel blocker and potent, selective ?1A-adrenoceptor receptor antagonist.

AD57 (hydrochloride)

C3080-1 1 mg
EUR 141.6
Description: IC50: 2 nM: blocks the receptor tyrosine kinase RET in Drosophila.AD57, as a polypharmacological cancer therapeutic, is designed to regulate multiple targets related to cancer.

AD57 (hydrochloride)

C3080-10 10 mg
EUR 714
Description: IC50: 2 nM: blocks the receptor tyrosine kinase RET in Drosophila.AD57, as a polypharmacological cancer therapeutic, is designed to regulate multiple targets related to cancer.

AD57 (hydrochloride)

C3080-5 5 mg
EUR 428.4
Description: IC50: 2 nM: blocks the receptor tyrosine kinase RET in Drosophila.AD57, as a polypharmacological cancer therapeutic, is designed to regulate multiple targets related to cancer.

Pargyline (hydrochloride)

C3106-1000 1 g
EUR 139.2
Description: IC50: 11.52 nM: inhibits monoamine oxidase (MAO) type A (MAO-A).IC50: 8.2 nM: blocks MAO type B (MAO-B).Pargyline, an irreversible and non-selective inhibitor of MAO, is used to treat moderate hypertension and cancer cells.

Pargyline (hydrochloride)

C3106-5000 5 g
EUR 410.4
Description: IC50: 11.52 nM: inhibits monoamine oxidase (MAO) type A (MAO-A).IC50: 8.2 nM: blocks MAO type B (MAO-B).Pargyline, an irreversible and non-selective inhibitor of MAO, is used to treat moderate hypertension and cancer cells.

Clenbuterol (hydrochloride)

C3119-100 100 mg
EUR 258
Description: Clenbuterol is a sympathomimetic ?2-adrenoceptor agonist. ?2-adrenoceptor agonists, mainly long-acting ?2-adrenoceptor agonists, are an important pharmacological approach to induce bronchodilation in patients with chronic obstructive pulmonary disease.

Clenbuterol (hydrochloride)

C3119-25 25 mg
EUR 130.8
Description: Clenbuterol is a sympathomimetic ?2-adrenoceptor agonist. ?2-adrenoceptor agonists, mainly long-acting ?2-adrenoceptor agonists, are an important pharmacological approach to induce bronchodilation in patients with chronic obstructive pulmonary disease.

Clenbuterol (hydrochloride)

C3119-5.1 10 mM (in 1mL DMSO)
EUR 135.6
Description: Clenbuterol is a sympathomimetic ?2-adrenoceptor agonist. ?2-adrenoceptor agonists, mainly long-acting ?2-adrenoceptor agonists, are an important pharmacological approach to induce bronchodilation in patients with chronic obstructive pulmonary disease.

Clenbuterol (hydrochloride)

C3119-50 50 mg
EUR 189.6
Description: Clenbuterol is a sympathomimetic ?2-adrenoceptor agonist. ?2-adrenoceptor agonists, mainly long-acting ?2-adrenoceptor agonists, are an important pharmacological approach to induce bronchodilation in patients with chronic obstructive pulmonary disease.

CBL0137 (hydrochloride)

C3192-10 10 mg
EUR 529.2
Description: EC50: 0.37 ?M for activating p53; 0.47 ?M for inhibiting NF-?B CBL0137 (hydrochloride) is a curaxin that activates p53 and inhibits NF-?B.

CBL0137 (hydrochloride)

C3192-25 25 mg
EUR 1071.6
Description: EC50: 0.37 ?M for activating p53; 0.47 ?M for inhibiting NF-?B CBL0137 (hydrochloride) is a curaxin that activates p53 and inhibits NF-?B.

CBL0137 (hydrochloride)

C3192-5 5 mg
EUR 331.2
Description: EC50: 0.37 ?M for activating p53; 0.47 ?M for inhibiting NF-?B CBL0137 (hydrochloride) is a curaxin that activates p53 and inhibits NF-?B.

CBL0137 (hydrochloride)

C3192-5.1 10 mM (in 1mL DMSO)
EUR 282
Description: EC50: 0.37 ?M for activating p53; 0.47 ?M for inhibiting NF-?B CBL0137 (hydrochloride) is a curaxin that activates p53 and inhibits NF-?B.

CBL0137 (hydrochloride)

C3192-50 50 mg
EUR 1851.6
Description: EC50: 0.37 ?M for activating p53; 0.47 ?M for inhibiting NF-?B CBL0137 (hydrochloride) is a curaxin that activates p53 and inhibits NF-?B.

CPTH2 (hydrochloride)

C3208-10 10 mg
EUR 231.6
Description: CPTH2 is an inhibitor of HAT activity of Gcn5.

CPTH2 (hydrochloride)

C3208-5 5 mg
EUR 192
Description: CPTH2 is an inhibitor of HAT activity of Gcn5.

Clinafloxacin (hydrochloride)

C3345-100 100 mg
EUR 184.8
Description: Clinafloxacin is a broad-spectrum antibiotic of the quinolone carboxylic acid category that inhibits both DNA gyrase and topoisomerase IV dually in Streptococcus pneumonia. Clinafloxacin, a fluoroquinolone, is currently in development for oral and intravenous therapy of serious infections.

Clinafloxacin (hydrochloride)

C3345-1000 1 g
EUR 686.4
Description: Clinafloxacin is a broad-spectrum antibiotic of the quinolone carboxylic acid category that inhibits both DNA gyrase and topoisomerase IV dually in Streptococcus pneumonia. Clinafloxacin, a fluoroquinolone, is currently in development for oral and intravenous therapy of serious infections.

Clinafloxacin (hydrochloride)

C3345-250 250 mg
EUR 309.6
Description: Clinafloxacin is a broad-spectrum antibiotic of the quinolone carboxylic acid category that inhibits both DNA gyrase and topoisomerase IV dually in Streptococcus pneumonia. Clinafloxacin, a fluoroquinolone, is currently in development for oral and intravenous therapy of serious infections.

Clinafloxacin (hydrochloride)

C3345-500 500 mg
EUR 459.6
Description: Clinafloxacin is a broad-spectrum antibiotic of the quinolone carboxylic acid category that inhibits both DNA gyrase and topoisomerase IV dually in Streptococcus pneumonia. Clinafloxacin, a fluoroquinolone, is currently in development for oral and intravenous therapy of serious infections.

Isoxsuprine (hydrochloride)

C3347-10000 10 g
EUR 145.2
Description: Isoxsuprine is a modulator of ?2 adrenoreceptor and has agonist or antagonist effects.The ?2 adrenoceptors are a class of G protein-coupled receptors that are targets for epinephrine.

Isoxsuprine (hydrochloride)

C3347-5.1 10 mM (in 1mL DMSO)
EUR 135.6
Description: Isoxsuprine is a modulator of ?2 adrenoreceptor and has agonist or antagonist effects.The ?2 adrenoceptors are a class of G protein-coupled receptors that are targets for epinephrine.

DAPI (hydrochloride)

C3362-10 10 mg
EUR 146.4

DAPI (hydrochloride)

C3362-25 25 mg
EUR 240

DAPI (hydrochloride)

C3362-5 5 mg
EUR 111.6

Inhibitory Potential of Polyclonal Camel Antibodies towards New Delhi Metallo-β-lactamase-1 (NDM-1)

New Delhi Metallo-β-lactamase-1 (NDM-1) is probably the most prevalent kind of metallo-β-lactamase, in a position to hydrolyze virtually all antibiotics of the β-lactam group, resulting in multidrug-resistant micro organism. Up to now, there aren’t any clinically related inhibitors to combat NDM-1. Using dromedary polyclonal antibody inhibitors towards NDM-1 represents a promising new class of molecules with inhibitory exercise.

Within the present research, immunoreactivities of dromedary Immunoglobulin G (IgG) isotypes containing heavy-chain and standard antibodies had been examined after profitable immunization of dromedary utilizing growing quantities of the recombinant NDM-1 enzyme. Inhibition kinetic assays, carried out utilizing a spectrophotometric methodology with nitrocefin as a reporter substrate, demonstrated that IgG1, IgG2, and IgG3 had been in a position to inhibit not solely the hydrolytic exercise of NDM-1 but in addition Verona integron-encoded metallo-β-lactamase (VIM-1) (subclass B1) and L1 metallo-β-lactamase (L1) (subclass B3) with inhibitory focus (IC50) values starting from 100 to 0.04 μM.

Investigations on the flexibility of IgG subclasses to cut back the expansion of recombinant Escherichia coli BL21(DE3)/codon plus cells containing the recombinant plasmid expressing NDM-1, L1, or VIM-1 confirmed that the addition of IgGs (four and eight mg/L) to the cell tradition was unable to revive the susceptibility of carbapenems.

Apparently, IgGs had been in a position to work together with NDM-1, L1, and VIM-1 when examined on the periplasm extract of every cultured pressure. The inhibitory focus was within the micromolar vary for all β-lactams examined. A visualization of the 3D structural foundation utilizing the three enzyme Protein Knowledge Financial institution (PDB) recordsdata helps preliminarily the recorded inhibition of the three MBLs.

A Easy and Environment friendly Genetic Immunization Protocol for the Manufacturing of Extremely Particular Polyclonal and Monoclonal Antibodies towards the Native Type of Mammalian Proteins

 

We’ve got generated polyclonal and monoclonal antibodies by genetic immunization over the past twenty years. On this paper, we current our most profitable methodology acquired over these years and current the animals by which we obtained the very best charges of success. The method introduced is handy, simple, inexpensive, and generates antibodies towards mammalian proteins of their native type.

This protocol requires neither costly gear, resembling a gene gun, nor subtle methods such because the conjugation of gold microspheres, electroporation, or surgical procedure to inject in lymph nodes. The protocol introduced makes use of merely the purified plasmid expressing the protein of curiosity below a powerful promoter, which is injected at intramuscular and intradermal websites.

This method was examined in 5 species. Guinea pigs had been the animals of alternative for the manufacturing of polyclonal antibodies. Monoclonal antibodies could possibly be generated in mice by giving, as a final injection, a suspension of transfected cells. The antibodies detected their antigens of their native kinds. They had been extremely particular with very low non-specific background ranges, as assessed by immune-blots, immunocytochemistry, immunohistochemistry and circulation cytometry. We current herein an in depth and easy process to efficiently elevate particular antibodies towards native proteins.

Manufacturing of a polyclonal antibody towards inosine-uridine preferring nucleoside hydrolase of Acanthamoeba castellanii and its entry to prognosis of Acanthamoeba keratitis

 

Acanthamoeba keratitis (AK) is a uncommon illness however its prevalence all through the globe continues to develop, primarily as a result of elevated contact lens utilization. Since early-stage signs related to AK carefully resemble these from different corneal infections, correct prognosis is tough and this typically leads to delayed therapy and exacerbation of the illness, which might result in everlasting visible impairment. Accordingly, creating a speedy Acanthamoeba-specific diagnostic methodology is very desired.

Within the current research, a speedy and . Among the many huge portions of proteins secreted by the pathogenic Acanthamoeba, an open studying body of the inosine-uridine preferring nucleoside hyddifferential methodology for AK prognosis was developed utilizing the secretory proteins derived from the pathogenic Acanthamoebarolase (IPNH) gene was obtained. After expressing and purifying the IPNH protein utilizing the pGEX 4T-Three vector system, mice had been immunized with the purified proteins for polyclonal antibody technology.

Western blot was carried out utilizing protein lysates of the human corneal cell, non-pathogenic amoeba, pathogenic amoeba, and scientific amoeba isolate together with lysates from different causes of keratitis resembling Staphylococcus aureus, Pseudomonas aeruginosa, and Fusarium solani to verify Acanthamoeba-specificity.

Western blot utilizing the polyclonal IPNH antibody revealed that IPNH was Acanthamoeba-specific since these proteins had been solely noticed in lysates of Acanthamoeba origin or its tradition media. Our findings point out that the IPNH antibody of Acanthamoeba might function a possible agent for speedy and differential AK prognosis.

Aquaphile Coelenterazine h, lyophilized solid

9-10127
  • EUR 550.80
  • EUR 199.20
  • 100uG
  • 50uG
Description: Minimum order quantity: 1 unit of 50uG

CF568 goat anti-mouse IgG(H+L)

9-20100
  • EUR 271.20
  • EUR 277.20
  • 0.5mL
  • 1mg
Description: Minimum order quantity: 1 unit of 1mg

CF568 goat anti-mouse IgG(H+L), highly cross-adsorbed

9-20101
  • EUR 312.00
  • EUR 319.20
  • 0.5mL
  • 1mg
Description: Minimum order quantity: 1 unit of 1mg

CF568 goat anti-rabbit IgG(H+L)

9-20102
  • EUR 271.20
  • EUR 277.20
  • 0.5mL
  • 1mg
Description: Minimum order quantity: 1 unit of 1mg

CF568 goat anti-rabbit IgG(H+L), highly cross-adsorbed

9-20103
  • EUR 312.00
  • EUR 319.20
  • 0.5mL
  • 1mg
Description: Minimum order quantity: 1 unit of 1mg

CF568 goat anti-chicken IgY (IgG) (H+L), highly cross-adsorbed

9-20104
  • EUR 312.00
  • EUR 319.20
  • 0.5mL
  • 1mg
Description: Minimum order quantity: 1 unit of 1mg

CF568 donkey anti-mouse IgG(H+L), highly cross-adsorbed

9-20105
  • EUR 312.00
  • EUR 319.20
  • 0.5mL
  • 1mg
Description: Minimum order quantity: 1 unit of 1mg

CF568 donkey anti-goat IgG(H+L), highly cross-adsorbed

9-20106
  • EUR 312.00
  • EUR 319.20
  • 0.5mL
  • 1mg
Description: Minimum order quantity: 1 unit of 1mg

CF568 rabbit anti-goat IgG(H+L)

9-20107
  • EUR 271.20
  • EUR 277.20
  • 0.5mL
  • 1mg
Description: Minimum order quantity: 1 unit of 1mg

CF568 goat anti-guinea pig IgG(H+L)

9-20108
  • EUR 271.20
  • EUR 277.20
  • 0.5mL
  • 1mg
Description: Minimum order quantity: 1 unit of 1mg

CF594 goat anti-mouse IgG(H+L)

9-20110
  • EUR 271.20
  • EUR 277.20
  • 0.5mL
  • 1mg
Description: Minimum order quantity: 1 unit of 1mg

CF594 goat anti-mouse IgG(H+L), highly cross-adsorbed

9-20111
  • EUR 312.00
  • EUR 319.20
  • 0.5mL
  • 1mg
Description: Minimum order quantity: 1 unit of 1mg

CF594 goat anti-rabbit IgG(H+L)

9-20112
  • EUR 271.20
  • EUR 277.20
  • 0.5mL
  • 1mg
Description: Minimum order quantity: 1 unit of 1mg

CF594 goat anti-rabbit IgG(H+L), highly cross-adsorbed

9-20113
  • EUR 312.00
  • EUR 319.20
  • 0.5mL
  • 1mg
Description: Minimum order quantity: 1 unit of 1mg

CF594 goat anti-chicken IgY (IgG) (H+L), highly cross-adsorbed

9-20114
  • EUR 312.00
  • EUR 319.20
  • 0.5mL
  • 1mg
Description: Minimum order quantity: 1 unit of 1mg

CF594 donkey anti-mouse IgG(H+L), highly cross-adsorbed

9-20115
  • EUR 312.00
  • EUR 319.20
  • 0.5mL
  • 1mg
Description: Minimum order quantity: 1 unit of 1mg

CF594 donkey anti-goat IgG(H+L), highly cross-adsorbed

9-20116
  • EUR 312.00
  • EUR 319.20
  • 0.5mL
  • 1mg
Description: Minimum order quantity: 1 unit of 1mg

CF594 rabbit anti-goat IgG(H+L)

9-20117
  • EUR 271.20
  • EUR 277.20
  • 0.5mL
  • 1mg
Description: Minimum order quantity: 1 unit of 1mg

CF594 goat anti-guinea pig IgG(H+L)

9-20118
  • EUR 271.20
  • EUR 277.20
  • 0.5mL
  • 1mg
Description: Minimum order quantity: 1 unit of 1mg

CF633 goat anti-mouse IgG(H+L)

9-20120
  • EUR 271.20
  • EUR 277.20
  • 0.5mL
  • 1mg
Description: Minimum order quantity: 1 unit of 1mg

CF633 goat anti-mouse IgG(H+L), highly cross-adsorbed

9-20121
  • EUR 319.20
  • EUR 326.40
  • 0.5mL
  • 1mg
Description: Minimum order quantity: 1 unit of 1mg

CF633 goat anti-rabbit IgG(H+L)

9-20122
  • EUR 271.20
  • EUR 277.20
  • 0.5mL
  • 1mg
Description: Minimum order quantity: 1 unit of 1mg

CF633 goat anti-rabbit IgG(H+L), highly cross-adsorbed

9-20123
  • EUR 312.00
  • EUR 319.20
  • 0.5mL
  • 1mg
Description: Minimum order quantity: 1 unit of 1mg

CF633 donkey anti-mouse IgG(H+L), highly cross-adsorbed

9-20124
  • EUR 312.00
  • EUR 319.20
  • 0.5mL
  • 1mg
Description: Minimum order quantity: 1 unit of 1mg

CF633 donkey anti-rabbit IgG(H+L), highly cross-adsorbed

9-20125
  • EUR 312.00
  • EUR 319.20
  • 0.5mL
  • 1mg
Description: Minimum order quantity: 1 unit of 1mg

CF633 goat anti-chicken IgY (IgG) (H+L), highly cross-adsorbed

9-20126
  • EUR 312.00
  • EUR 319.20
  • 0.5mL
  • 1mg
Description: Minimum order quantity: 1 unit of 1mg

CF633 donkey anti-goat IgG(H+L), highly cross-adsorbed

9-20127
  • EUR 312.00
  • EUR 319.20
  • 0.5mL
  • 1mg
Description: Minimum order quantity: 1 unit of 1mg

CF633 rabbit anti-goat IgG(H+L)

9-20128
  • EUR 271.20
  • EUR 277.20
  • 0.5mL
  • 1mg
Description: Minimum order quantity: 1 unit of 1mg

CF633 goat anti-guinea pig IgG(H+L)

9-20129
  • EUR 271.20
  • EUR 277.20
  • 0.5mL
  • 1mg
Description: Minimum order quantity: 1 unit of 1mg

CF633 goat anti-human IgG(H+L), highly cross-adsorbed

9-20132
  • EUR 312.00
  • EUR 319.20
  • 0.5mL
  • 1mg
Description: Minimum order quantity: 1 unit of 1mg

CF633 goat anti-rat IgG(H+L), highly cross-adsorbed

9-20133
  • EUR 312.00
  • EUR 319.20
  • 0.5mL
  • 1mg
Description: Minimum order quantity: 1 unit of 1mg

CF633 donkey anti-sheep IgG(H+L), highly cross-adsorbed

9-20134
  • EUR 312.00
  • EUR 319.20
  • 0.5mL
  • 1mg
Description: Minimum order quantity: 1 unit of 1mg

CF633 rabbit anti-rat IgG(H+L), highly cross-adsorbed

9-20135
  • EUR 312.00
  • EUR 319.20
  • 0.5mL
  • 1mg
Description: Minimum order quantity: 1 unit of 1mg

CF633 rabbit anti-mouse IgG(H+L), highly cross-adsorbed

9-20136
  • EUR 312.00
  • EUR 319.20
  • 0.5mL
  • 1mg
Description: Minimum order quantity: 1 unit of 1mg

CF633 donkey anti-rat IgG(H+L), highly cross-adsorbed

9-20137
  • EUR 312.00
  • EUR 319.20
  • 0.5mL
  • 1mg
Description: Minimum order quantity: 1 unit of 1mg

CF633 goat anti-swine IgG(H+L)

9-20138
  • EUR 271.20
  • EUR 277.20
  • 0.5mL
  • 1mg
Description: Minimum order quantity: 1 unit of 1mg

CF350 goat anti-mouse IgG(H+L)

9-20140
  • EUR 271.20
  • EUR 277.20
  • 0.5mL
  • 1mg
Description: Minimum order quantity: 1 unit of 1mg

CF350 goat anti-rabbit IgG(H+L)

9-20141
  • EUR 271.20
  • EUR 277.20
  • 0.5mL
  • 1mg
Description: Minimum order quantity: 1 unit of 1mg

CF350 donkey anti-goat IgG(H+L), highly cross-adsorbed

9-20142
  • EUR 312.00
  • EUR 319.20
  • 0.5mL
  • 1mg
Description: Minimum order quantity: 1 unit of 1mg

CF350 goat anti-mouse IgG(H+L), highly cross-adsorbed

9-20143
  • EUR 312.00
  • EUR 319.20
  • 0.5mL
  • 1mg
Description: Minimum order quantity: 1 unit of 1mg

CF350 goat anti-rabbit IgG(H+L), highly cross-adsorbed

9-20144
  • EUR 312.00
  • EUR 319.20
  • 0.5mL
  • 1mg
Description: Minimum order quantity: 1 unit of 1mg

CF350 goat anti-rat IgG(H+L), highly cross-adsorbed

9-20147
  • EUR 312.00
  • EUR 319.20
  • 0.5mL
  • 1mg
Description: Minimum order quantity: 1 unit of 1mg

CF350 donkey anti-sheep IgG(H+L), highly cross-adsorbed

9-20148
  • EUR 312.00
  • EUR 319.20
  • 0.5mL
  • 1mg
Description: Minimum order quantity: 1 unit of 1mg

CF350 rabbit anti-mouse IgG(H+L), highly cross-adsorbed

9-20149
  • EUR 312.00
  • EUR 319.20
  • 0.5mL
  • 1mg
Description: Minimum order quantity: 1 unit of 1mg

CF594 donkey anti-rabbit IgG(H+L), highly cross-adsorbed

9-20152
  • EUR 312.00
  • EUR 319.20
  • 0.5mL
  • 1mg
Description: Minimum order quantity: 1 unit of 1mg

CF594 goat anti-human IgG(H+L), highly cross-adsorbed

9-20154
  • EUR 312.00
  • EUR 319.20
  • 0.5mL
  • 1mg
Description: Minimum order quantity: 1 unit of 1mg

CF594 goat anti-rat IgG(H+L), highly cross-adsorbed

9-20155
  • EUR 312.00
  • EUR 319.20
  • 0.5mL
  • 1mg
Description: Minimum order quantity: 1 unit of 1mg

CF594 donkey anti-sheep IgG(H+L), highly cross-adsorbed

9-20156
  • EUR 312.00
  • EUR 319.20
  • 0.5mL
  • 1mg
Description: Minimum order quantity: 1 unit of 1mg

CF594 rabbit anti-rat IgG(H+L), highly cross-adsorbed

9-20157
  • EUR 312.00
  • EUR 319.20
  • 0.5mL
  • 1mg
Description: Minimum order quantity: 1 unit of 1mg

CF594 rabbit anti-mouse IgG(H+L), highly cross-adsorbed

9-20158
  • EUR 312.00
  • EUR 319.20
  • 0.5mL
  • 1mg
Description: Minimum order quantity: 1 unit of 1mg

CF594 donkey anti-rat IgG(H+L), highly cross-adsorbed

9-20159
  • EUR 312.00
  • EUR 319.20
  • 0.5mL
  • 1mg
Description: Minimum order quantity: 1 unit of 1mg

CF594 goat anti-swine IgG(H+L)

9-20160
  • EUR 271.20
  • EUR 277.20
  • 0.5mL
  • 1mg
Description: Minimum order quantity: 1 unit of 1mg

CF594 rabbit anti-chicken IgY ( IgG) (H+L)

9-20164
  • EUR 271.20
  • EUR 277.20
  • 0.5mL
  • 1mg
Description: Minimum order quantity: 1 unit of 1mg

CF633 rabbit anti-chicken IgY (IgG) (H+L)

9-20165
  • EUR 271.20
  • EUR 277.20
  • 0.5mL
  • 1mg
Description: Minimum order quantity: 1 unit of 1mg

CF488A donkey anti-chicken IgY (IgG) (H+L), highly cross-adsorbed

9-20166
  • EUR 312.00
  • EUR 319.20
  • 0.5mL
  • 1mg
Description: Minimum order quantity: 1 unit of 1mg

CF594 donkey anti-chicken IgY (IgG) (H+L), highly cross-adsorbed

9-20167
  • EUR 312.00
  • EUR 319.20
  • 0.5mL
  • 1mg
Description: Minimum order quantity: 1 unit of 1mg

CF633 donkey anti-chicken IgY (IgG) (H+L), highly cross-adsorbed

9-20168
  • EUR 312.00
  • EUR 319.20
  • 0.5mL
  • 1mg
Description: Minimum order quantity: 1 unit of 1mg

CF488A donkey anti-guinea pig IgG(H+L), highly cross-adsorbed

9-20169
  • EUR 312.00
  • EUR 319.20
  • 0.5mL
  • 1mg
Description: Minimum order quantity: 1 unit of 1mg

CF594 donkey anti-guinea pig IgG(H+L), highly cross-adsorbed

9-20170
  • EUR 312.00
  • EUR 319.20
  • 0.5mL
  • 1mg
Description: Minimum order quantity: 1 unit of 1mg

CF633 donkey anti-guinea pig IgG(H+L), highly cross-adsorbed

9-20171
  • EUR 312.00
  • EUR 319.20
  • 0.5mL
  • 1mg
Description: Minimum order quantity: 1 unit of 1mg

CF488A rabbit anti-sheep IgG(H+L), highly cross-adsorbed

9-20172
  • EUR 312.00
  • EUR 319.20
  • 0.5mL
  • 1mg
Description: Minimum order quantity: 1 unit of 1mg

CF594 rabbit anti-sheep IgG(H+L), highly cross-adsorbed

9-20173
  • EUR 312.00
  • EUR 319.20
  • 0.5mL
  • 1mg
Description: Minimum order quantity: 1 unit of 1mg

CF594 rabbit anti-sheep IgG(H+L), highly cross-adsorbed

9-20174
  • EUR 312.00
  • EUR 319.20
  • 0.5mL
  • 1mg
Description: Minimum order quantity: 1 unit of 1mg

CF640R goat anti-mouse IgG(H+L), highly cross-adsorbed

9-20175
  • EUR 312.00
  • EUR 319.20
  • 0.5mL
  • 1mg
Description: Minimum order quantity: 1 unit of 1mg

CF640R goat anti-rabbit IgG(H+L), highly cross-adsorbed

9-20176
  • EUR 312.00
  • EUR 319.20
  • 0.5mL
  • 1mg
Description: Minimum order quantity: 1 unit of 1mg

CF640R donkey anti-mouse IgG(H+L), highly cross-adsorbed

9-20177
  • EUR 312.00
  • EUR 319.20
  • 0.5mL
  • 1mg
Description: Minimum order quantity: 1 unit of 1mg

CF640R donkey anti-rabbit IgG(H+L), highly cross-adsorbed

9-20178
  • EUR 312.00
  • EUR 319.20
  • 0.5mL
  • 1mg
Description: Minimum order quantity: 1 unit of 1mg

CF640R donkey anti-goat IgG(H+L), highly cross-adsorbed

9-20179
  • EUR 312.00
  • EUR 319.20
  • 0.5mL
  • 1mg
Description: Minimum order quantity: 1 unit of 1mg

CF405M goat anti-mouse IgG(H+L)

9-20180
  • EUR 271.20
  • EUR 277.20
  • 0.5 mL
  • 1mg
Description: Minimum order quantity: 1 unit of 1mg

CF405M goat anti-rabbit IgG(H+L)

9-20181
  • EUR 271.20
  • EUR 277.20
  • 0.5 mL
  • 1mg
Description: Minimum order quantity: 1 unit of 1mg

CF405M goat anti-mouse IgG(H+L), highly cross-adsorbed

9-20182
  • EUR 312.00
  • EUR 319.20
  • 0.5mL
  • 1mg
Description: Minimum order quantity: 1 unit of 1mg

Biotin goat anti-mouse IgG(H+L)

9-20183
  • EUR 271.20
  • EUR 277.20
  • 0.5mL
  • 1mg
Description: Minimum order quantity: 1 unit of 1mg

Biotin goat anti-mouse IgG(H+L), highly cross-adsorbed

9-20184
  • EUR 312.00
  • EUR 319.20
  • 0.5mL
  • 1mg
Description: Minimum order quantity: 1 unit of 1mg

Biotin goat anti-rabbit IgG(H+L)

9-20185
  • EUR 271.20
  • EUR 277.20
  • 0.5mL
  • 1mg
Description: Minimum order quantity: 1 unit of 1mg

Biotin goat anti-rabbit IgG(H+L), highly cross-adsorbed

9-20186
  • EUR 312.00
  • EUR 319.20
  • 0.5mL
  • 1mg
Description: Minimum order quantity: 1 unit of 1mg

Biotin donkey anti-goat IgG(H+L), highly cross-adsorbed

9-20189
  • EUR 312.00
  • EUR 319.20
  • 0.5mL
  • 1mg
Description: Minimum order quantity: 1 unit of 1mg

Biotin donkey anti-mouse IgG(H+L), highly cross-adsorbed

9-20190
  • EUR 312.00
  • EUR 319.20
  • 0.5mL
  • 1mg
Description: Minimum order quantity: 1 unit of 1mg

Biotin donkey anti-rabbit IgG(H+L), highly cross-adsorbed

9-20191
  • EUR 312.00
  • EUR 319.20
  • 0.5mL
  • 1mg
Description: Minimum order quantity: 1 unit of 1mg

CF640R goat anti-mouse IgG(H+L)

9-20197
  • EUR 271.20
  • EUR 277.20
  • 0.5mL
  • 1mg
Description: Minimum order quantity: 1 unit of 1mg

CF350 goat anti-guinea pig IgG(H+L)

9-20198
  • EUR 271.20
  • EUR 277.20
  • 0.5mL
  • 1mg
Description: Minimum order quantity: 1 unit of 1mg

CF640R donkey anti-rat IgG(H+L), highly cross-adsorbed

9-20199
  • EUR 312.00
  • EUR 319.20
  • 0.5mL
  • 1mg
Description: Minimum order quantity: 1 unit of 1mg

CF640R rabbit anti-mouseIgG(H+L), highly cross-adsorbed

9-20200
  • EUR 283.20
  • EUR 290.40
  • 0.5mL
  • 1mg
Description: Minimum order quantity: 1 unit of 1mg

CF640R rabbit anti-rat IgG(H+L), highly cross-adsorbed

9-20201
  • EUR 283.20
  • EUR 290.40
  • 0.5mL
  • 1mg
Description: Minimum order quantity: 1 unit of 1mg

CF640R goat anti-rabbit IgG(H+L)

9-20202
  • EUR 271.20
  • EUR 277.20
  • 0.5mL
  • 1mg
Description: Minimum order quantity: 1 unit of 1mg

CF488A chicken anti-mouse IgG(H+L)

9-20208
  • EUR 271.20
  • EUR 277.20
  • 0.5mL
  • 1mg
Description: Minimum order quantity: 1 unit of 1mg

CF488A chicken anti-rabbit IgG(H+L)

9-20209
  • EUR 271.20
  • EUR 277.20
  • 0.5mL
  • 1mg
Description: Minimum order quantity: 1 unit of 1mg

CF594 chicken anti-mouse IgG(H+L)

9-20221
  • EUR 271.20
  • EUR 277.20
  • 0.5mL
  • 1mg
Description: Minimum order quantity: 1 unit of 1mg

CF633 chicken anti-mouse IgG(H+L)

9-20222
  • EUR 271.20
  • EUR 277.20
  • 0.5mL
  • 1mg
Description: Minimum order quantity: 1 unit of 1mg

CF594 chicken anti-rabbit IgG(H+L)

9-20223
  • EUR 271.20
  • EUR 277.20
  • 0.5mL
  • 1mg
Description: Minimum order quantity: 1 unit of 1mg

CF633 chicken anti-rabbit IgG(H+L)

9-20224
  • EUR 271.20
  • EUR 277.20
  • 0.5mL
  • 1mg
Description: Minimum order quantity: 1 unit of 1mg

CF488A chicken anti-goat IgG(H+L)

9-20225
  • EUR 271.20
  • EUR 277.20
  • 0.5mL
  • 1mg
Description: Minimum order quantity: 1 unit of 1mg

CF594 chicken anti-goat IgG(H+L)

9-20226
  • EUR 271.20
  • EUR 277.20
  • 0.5mL
  • 1mg
Description: Minimum order quantity: 1 unit of 1mg

CF633 chicken anti-goat IgG(H+L)

9-20227
  • EUR 271.20
  • EUR 277.20
  • 0.5mL
  • 1mg
Description: Minimum order quantity: 1 unit of 1mg

CF555 goat anti-human IgG(H+L), highly cross-adsorbed

9-20230
  • EUR 312.00
  • EUR 319.20
  • 0.5mL
  • 1mg
Description: Minimum order quantity: 1 unit of 1mg

CF555 goat anti-mouse IgG(H+L), highly cross-adsorbed

9-20231
  • EUR 312.00
  • EUR 319.20
  • 0.5mL
  • 1mg
Description: Minimum order quantity: 1 unit of 1mg

CF555 goat anti-rabbit IgG(H+L), highly cross-adsorbed

9-20232
  • EUR 312.00
  • EUR 319.20
  • 0.5mL
  • 1mg
Description: Minimum order quantity: 1 unit of 1mg

CF555 goat anti-rat IgG(H+L), highly cross-adsorbed

9-20233
  • EUR 312.00
  • EUR 319.20
  • 0.5mL
  • 1mg
Description: Minimum order quantity: 1 unit of 1mg

CF555 donkey anti-sheep IgG(H+L), highly cross-adsorbed

9-20234
  • EUR 312.00
  • EUR 319.20
  • 0.5mL
  • 1mg
Description: Minimum order quantity: 1 unit of 1mg

CF555 rabbit anti-mouse IgG(H+L), highly cross-adsorbed

9-20235
  • EUR 312.00
  • EUR 319.20
  • 0.5mL
  • 1mg
Description: Minimum order quantity: 1 unit of 1mg

CF555 goat anti-swine IgG(H+L)

9-20236
  • EUR 271.20
  • EUR 277.20
  • 0.5mL
  • 1mg
Description: Minimum order quantity: 1 unit of 1mg

CF680 rabbit anti-guinea pig IgG(H+L)

9-20243
  • EUR 306.00
  • EUR 312.00
  • 0.5mL
  • 1mg
Description: Minimum order quantity: 1 unit of 1mg

CF770 rabbit anti-guinea pig IgG(H+L)

9-20244
  • EUR 306.00
  • EUR 312.00
  • 0.5mL
  • 1mg
Description: Minimum order quantity: 1 unit of 1mg

CF350 donkey anti-chicken IgY (IgG) (H+L), highly cross-adsorbed

9-20275
  • EUR 312.00
  • EUR 319.20
  • 0.5mL
  • 1mg
Description: Minimum order quantity: 1 unit of 1mg

CF555 donkey anti-guinea pig IgG (H+L), highly cross-adsorbed

9-20276
  • EUR 312.00
  • EUR 319.20
  • 0.5mL
  • 1mg
Description: Minimum order quantity: 1 unit of 1mg

CF647 goat anti-human IgG(H+L), highly cross-adsorbed

9-20280
  • EUR 312.00
  • EUR 319.20
  • 0.5mL
  • 1mg
Description: Minimum order quantity: 1 unit of 1mg

CF647 goat anti-mouse IgG(H+L), highly cross-adsorbed

9-20281
  • EUR 312.00
  • EUR 319.20
  • 0.5mL
  • 1mg
Description: Minimum order quantity: 1 unit of 1mg

CF647 goat anti-rabbit IgG(H+L), highly cross-adsorbed

9-20282
  • EUR 312.00
  • EUR 319.20
  • 0.5mL
  • 1mg
Description: Minimum order quantity: 1 unit of 1mg

CF647 goat anti-rat IgG(H+L), highly cross-adsorbed

9-20283
  • EUR 312.00
  • EUR 319.20
  • 0.5mL
  • 1mg
Description: Minimum order quantity: 1 unit of 1mg

CF647 donkey anti-sheep IgG(H+L), highly cross-adsorbed

9-20284
  • EUR 312.00
  • EUR 319.20
  • 0.5mL
  • 1mg
Description: Minimum order quantity: 1 unit of 1mg

CF647 rabbit anti-mouse IgG(H+L), highly cross-adsorbed

9-20285
  • EUR 312.00
  • EUR 319.20
  • 0.5mL
  • 1mg
Description: Minimum order quantity: 1 unit of 1mg

CF647 goat anti-swine IgG(H+L)

9-20286
  • EUR 271.20
  • EUR 277.20
  • 0.5mL
  • 1mg
Description: Minimum order quantity: 1 unit of 1mg

CF488A Bovine anti-goat IgG(H+L), highly cross-adsorbed

9-20293
  • EUR 312.00
  • EUR 319.20
  • 0.5mL
  • 1mg
Description: Minimum order quantity: 1 unit of 1mg

CF568 Bovine anti-goat IgG(H+L), highly cross-adsorbed

9-20294
  • EUR 312.00
  • EUR 319.20
  • 0.5mL
  • 1mg
Description: Minimum order quantity: 1 unit of 1mg

CF594 Bovine anti-goat IgG(H+L), highly cross-adsorbed

9-20295
  • EUR 312.00
  • EUR 319.20
  • 0.5mL
  • 1mg
Description: Minimum order quantity: 1 unit of 1mg

CF633 Bovine anti-goat IgG(H+L), highly cross-adsorbed

9-20296
  • EUR 312.00
  • EUR 319.20
  • 0.5mL
  • 1mg
Description: Minimum order quantity: 1 unit of 1mg

CF640R Bovine anti-goat IgG(H+L), highly cross-adsorbed

9-20297
  • EUR 312.00
  • EUR 319.20
  • 0.5mL
  • 1mg
Description: Minimum order quantity: 1 unit of 1mg

CF543 Goat anti-mouse IgG (H+L), highly cross-adsorbed

9-20299
  • EUR 312.00
  • EUR 319.20
  • 0.5mL
  • 1mg
Description: Minimum order quantity: 1 unit of 1mg

CF543 Goat anti-rabbit IgG (H+L), highly cross-adsorbed

9-20300
  • EUR 312.00
  • EUR 319.20
  • 0.5mL
  • 1mg
Description: Minimum order quantity: 1 unit of 1mg

CF568 Goat anti-mouse IgG (H+L), highly cross-adsorbed (min X Rat)

9-20301
  • EUR 388.80
  • EUR 396.00
  • 0.5mL
  • 1mg
Description: Minimum order quantity: 1 unit of 1mg

CF488A Goat anti-mouse IgG (H+L), highly cross-adsorbed (min X Rat)

9-20302
  • EUR 388.80
  • EUR 396.00
  • 0.5mL
  • 1mg
Description: Minimum order quantity: 1 unit of 1mg

CF594 Goat anti-mouse IgG (H+L), highly cross-adsorbed (min X Rat)

9-20303
  • EUR 388.80
  • EUR 396.00
  • 0.5mL
  • 1mg
Description: Minimum order quantity: 1 unit of 1mg

CF640R Goat anti-mouse IgG (H+L), highly cross-adsorbed (min X Rat)

9-20304
  • EUR 388.80
  • EUR 396.00
  • 0.5mL
  • 1mg
Description: Minimum order quantity: 1 unit of 1mg

CF543 Donkey anti-mouse IgG(H+L), highly cross-adsorbed

9-20305
  • EUR 312.00
  • EUR 319.20
  • 0.5mL
  • 1mg
Description: Minimum order quantity: 1 unit of 1mg

CF543 goat anti-mouse IgG(H+L)

9-20306
  • EUR 271.20
  • EUR 277.20
  • 0.5mL
  • 1mg
Description: Minimum order quantity: 1 unit of 1mg

CF543 Rabbit anti-mouse IgG(H+L), highly cross-adsorbed

9-20307
  • EUR 312.00
  • EUR 319.20
  • 0.5mL
  • 1mg
Description: Minimum order quantity: 1 unit of 1mg

CF543 Donkey anti-rabbit IgG(H+L), highly cross-adsorbed

9-20308
  • EUR 312.00
  • EUR 319.20
  • 0.5mL
  • 1mg
Description: Minimum order quantity: 1 unit of 1mg

CF543 goat anti-rabbit IgG(H+L)

9-20309
  • EUR 271.20
  • EUR 277.20
  • 0.5mL
  • 1mg
Description: Minimum order quantity: 1 unit of 1mg

CF543 donkey anti-chicken IgY (IgG) (H+L), highly cross-adsorbed

9-20310
  • EUR 312.00
  • EUR 319.20
  • 0.5mL
  • 1mg
Description: Minimum order quantity: 1 unit of 1mg

CF543 goat anti-chicken IgY(H+L), highly cross-adsorbed

9-20311
  • EUR 312.00
  • EUR 319.20
  • 0.5mL
  • 1mg
Description: Minimum order quantity: 1 unit of 1mg

CF543 rabbit anti-chicken IgY (IgG) (H+L)

9-20312
  • EUR 271.20
  • EUR 277.20
  • 0.5mL
  • 1mg
Description: Minimum order quantity: 1 unit of 1mg

CF543 Bovine anti-goat IgG(H+L), highly cross-adsorbed

9-20313
  • EUR 312.00
  • EUR 319.20
  • 0.5mL
  • 1mg
Description: Minimum order quantity: 1 unit of 1mg

CF543 Donkey anti-goat IgG(H+L), highly cross-adsorbed

9-20314
  • EUR 312.00
  • EUR 319.20
  • 0.5mL
  • 1mg
Description: Minimum order quantity: 1 unit of 1mg

CF543 rabbit anti-goat IgG(H+L)

9-20315
  • EUR 271.20
  • EUR 277.20
  • 0.5mL
  • 1mg
Description: Minimum order quantity: 1 unit of 1mg

CF543 donkey anti-guinea pig IgG (H+L), highly cross-adsorbed

9-20316
  • EUR 312.00
  • EUR 319.20
  • 0.5mL
  • 1mg
Description: Minimum order quantity: 1 unit of 1mg

CF543 goat anti-guinea pig IgG(H+L)

9-20317
  • EUR 271.20
  • EUR 277.20
  • 0.5mL
  • 1mg
Description: Minimum order quantity: 1 unit of 1mg

CF543 donkey anti-human IgG(H+L), highly cross-adsorbed

9-20318
  • EUR 312.00
  • EUR 319.20
  • 0.5mL
  • 1mg
Description: Minimum order quantity: 1 unit of 1mg

CF543 goat anti-human IgG(H+L), highly cross-adsorbed

9-20319
  • EUR 312.00
  • EUR 319.20
  • 0.5mL
  • 1mg
Description: Minimum order quantity: 1 unit of 1mg

CF543 donkey anti-rat IgG(H+L), highly cross-adsorbed

9-20320
  • EUR 312.00
  • EUR 319.20
  • 0.5mL
  • 1mg
Description: Minimum order quantity: 1 unit of 1mg

CF543 goat anti-rat IgG(H+L), highly cross-adsorbed

9-20321
  • EUR 312.00
  • EUR 319.20
  • 0.5mL
  • 1mg
Description: Minimum order quantity: 1 unit of 1mg

CF543 donkey anti-sheep IgG(H+L), highly cross-adsorbed

9-20322
  • EUR 312.00
  • EUR 319.20
  • 0.5mL
  • 1mg
Description: Minimum order quantity: 1 unit of 1mg

CF543 rabbit anti-sheep IgG(H+L), highly cross-adsorbed

9-20323
  • EUR 312.00
  • EUR 319.20
  • 0.5mL
  • 1mg
Description: Minimum order quantity: 1 unit of 1mg

CF543 goat anti-swine IgG(H+L)

9-20324
  • EUR 271.20
  • EUR 277.20
  • 0.5mL
  • 1mg
Description: Minimum order quantity: 1 unit of 1mg

CF543 Goat anti-mouse IgG (H+L), highly cross-adsorbed (min X Rat)

9-20328
  • EUR 388.80
  • EUR 396.00
  • 0.5mL
  • 1mg
Description: Minimum order quantity: 1 unit of 1mg

CF350 Chicken Anti-Mouse IgG(H+L), 2 mg/mL

9-20331
  • EUR 277.20
  • EUR 271.20
  • EUR 144.00
  • 1mg
  • 0.5mL
  • 50uL
Description: Minimum order quantity: 1 unit of 50uL

CF350 Chicken Anti-Rabbit IgG(H+L), 2 mg/mL

9-20332
  • EUR 277.20
  • EUR 271.20
  • EUR 144.00
  • 1mg
  • 0.5mL
  • 50uL
Description: Minimum order quantity: 1 unit of 50uL

CF543 Chicken Anti-Goat IgG(H+L), 2 mg/mL

9-20333
  • EUR 277.20
  • EUR 271.20
  • EUR 144.00
  • 1mg
  • 0.5mL
  • 50uL
Description: Minimum order quantity: 1 unit of 50uL

CF543 Chicken Anti-Mouse IgG(H+L), 2 mg/mL

9-20334
  • EUR 277.20
  • EUR 271.20
  • EUR 144.00
  • 1mg
  • 0.5mL
  • 50uL
Description: Minimum order quantity: 1 unit of 50uL

CF543 Chicken Anti-Rabbit IgG(H+L), 2 mg/mL

9-20335
  • EUR 277.20
  • EUR 271.20
  • EUR 144.00
  • 1mg
  • 0.5mL
  • 50uL
Description: Minimum order quantity: 1 unit of 50uL

CF543 Rabbit Anit-Guinea Pig IgG(H+L), 2 mg/mL

9-20336
  • EUR 277.20
  • EUR 271.20
  • EUR 144.00
  • 1mg
  • 0.5mL
  • 50uL
Description: Minimum order quantity: 1 unit of 50uL

CF568 Chicken Anti-Goat IgG(H+L), 2 mg/mL

9-20337
  • EUR 277.20
  • EUR 271.20
  • EUR 144.00
  • 1mg
  • 0.5mL
  • 50uL
Description: Minimum order quantity: 1 unit of 50uL

CF568 Chicken Anti-Mouse IgG(H+L), 2 mg/mL

9-20338
  • EUR 277.20
  • EUR 271.20
  • EUR 144.00
  • 1mg
  • 0.5mL
  • 50uL
Description: Minimum order quantity: 1 unit of 50uL

CF568 Chicken Anti-Rabbit IgG(H+L), 2 mg/mL

9-20339
  • EUR 277.20
  • EUR 271.20
  • EUR 144.00
  • 1mg
  • 0.5mL
  • 50uL
Description: Minimum order quantity: 1 unit of 50uL

CF405M Goat anti-mouse IgG (H+L), highly cross-adsorbed (min X Rat), 2 mg/mL

9-20340
  • EUR 396.00
  • EUR 388.80
  • EUR 164.40
  • 1mg
  • 0.5mL
  • 50uL
Description: Minimum order quantity: 1 unit of 50uL

CF633 Goat anti-mouse IgG (H+L), highly cross-adsorbed (min X Rat), 2 mg/mL

9-20341
  • EUR 396.00
  • EUR 388.80
  • EUR 164.40
  • 1mg
  • 0.5mL
  • 50uL
Description: Minimum order quantity: 1 unit of 50uL

CF647 Goat Anti-Human IgM (mu chain), 2mg/mL

9-20346
  • EUR 248.40
  • EUR 164.40
  • 250uL
  • 50uL
Description: Minimum order quantity: 1 unit of 50uL

CF488A Goat Anti-Human IgM (mu chain), 2mg/mL

9-20347
  • EUR 248.40
  • EUR 164.40
  • 250uL
  • 50uL
Description: Minimum order quantity: 1 unit of 50uL

CF594 Goat Anti-Human IgM (mu chain), 2mg/mL

9-20348
  • EUR 248.40
  • EUR 164.40
  • 250uL
  • 50uL
Description: Minimum order quantity: 1 unit of 50uL

CF640R Goat Anti-Human IgM (mu chain), 2mg/mL

9-20349
  • EUR 248.40
  • EUR 164.40
  • 250uL
  • 50uL
Description: Minimum order quantity: 1 unit of 50uL

CF350 Donkey anti-mouse IgG(H+L), highly cross-adsorbed

9-20350
  • EUR 312.00
  • EUR 319.20
  • 0.5mL
  • 1mg
Description: Minimum order quantity: 1 unit of 1mg

CF350 Donkey anti-rabbit IgG(H+L), highly cross-adsorbed

9-20351
  • EUR 312.00
  • EUR 319.20
  • 0.5mL
  • 1mg
Description: Minimum order quantity: 1 unit of 1mg

R-phycoerythrin goat anti-mouse IgG(H+L), 0.5 mg/mL

9-20352
  • EUR 374.40
  • EUR 178.80
  • 1mL
  • 200uL
Description: Minimum order quantity: 1 unit of 200uL

R-phycoerythrin goat anti-rabbit IgG(H+L), 0.5 mg/mL

9-20353
  • EUR 374.40
  • EUR 178.80
  • 1mL
  • 200uL
Description: Minimum order quantity: 1 unit of 200uL

R-phycoerythrin goat anti-rat IgG(H+L), highly cross-adsorbed, 0.5 mg/mL

9-20354
  • EUR 410.40
  • EUR 193.20
  • 1mL
  • 200uL
Description: Minimum order quantity: 1 unit of 200uL

R-phycoerythrin goat anti-human IgG(H+L), highly cross-adsorbed, 0.5 mg/mL

9-20355
  • EUR 410.40
  • EUR 193.20
  • 1mL
  • 200uL
Description: Minimum order quantity: 1 unit of 200uL

CF405S Donkey anti-guinea pig IgG(H+L), highly cross-adsorbed, 2 mg/mL

9-20356
  • EUR 319.20
  • EUR 312.00
  • EUR 164.40
  • 1mg
  • 0.5mL
  • 50uL
Description: Minimum order quantity: 1 unit of 50uL

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