Evaluation of Laboratory Application of Camelid Sera Containing Heavy-Chain Polyclonal Antibody Against Recombinant CTLA-4 Protein. Cytotoxic T-lymphocyte-associated protein-4 (CTLA-4) is a critical negative immunomodulatory receptor that is normally expressed in activated T cells and noticeably, in many cancerous cells. Indeed, molecular detection of CTLA-4 protein is crucial in basic research. In this work, the extracellular domain of the […]
Efficient detection of eukaryotic calcium-sensing receptor
In direction of middle-up evaluation of polyclonal antibodies: subclass-specific N-glycosylation profiling of murine immunoglobulin G (IgG) by the use of HPLC-MS Lately, superior HPLC-MS methods based mostly on intact protein (“top-down”) or protein subunit (“middle-up/middle-down”) evaluation have been applied for the characterization of therapeutic monoclonal antibodies. Right here, we assess feasibility of middle-up/middle-down evaluation for polyclonal […]
In utero exposure to endogenous maternal polyclonal anti-Caspr2 antibody
Preparation and Characterization of Two Immunogens and Manufacturing of Polyclonal Antibody with Excessive Affinity and Specificity for Darunavir Darunavir (DRV) is a potent antiviral drug used for therapy of infections with human immunodeficiency virus (HIV). Efficient and protected therapy with DRV requires its therapeutic drug monitoring (TDM) in affected person’s plasma throughout remedy. To assist TDM of DRV, […]
Prokaryotic expression of PE8 protein from Mycobacterium tuberculosis
Improvement of a Extremely Delicate Enzyme-Linked Immunosorbent Assay for Mouse Soluble Epoxide Hydrolase Detection by Combining a Polyclonal Seize Antibody with a Nanobody Tracer Enzyme-linked immunosorbent assays (ELISA) for the detection of soluble epoxide hydrolase (sEH), a key enzyme within the metabolism of fatty acids and a biomarker, might more and more signify an essential diagnostic software. Nonetheless, […]
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